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hif 1 α inhibitor yc 1  (MedChemExpress)


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    Structured Review

    MedChemExpress hif 1 α inhibitor yc 1
    Hif 1 α Inhibitor Yc 1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 142 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hif+1+%CE%B1/LW6/pmc12813877-75-5-11
    Average 97 stars, based on 142 article reviews
    hif 1 α inhibitor yc 1 - by Bioz Stars, 2026-08
    97/100 stars

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    (A–D) UBE2S staining intensities: negative, weak, moderate, strong. (E) UBE2S IHC scores ( p < 0.001). (F–I) <t>HIF1</t> <t>α</t> staining intensities: negative, weak, moderate, strong. (J) HIF1 α IHC scores ( p = 0.004). (K–N) p110 α staining intensities: negative, weak, moderate, strong. (O) p110 α IHC scores ( p = 0.039). All micrographs shown at ×200 magnification.
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    (A–D) UBE2S staining intensities: negative, weak, moderate, strong. (E) UBE2S IHC scores ( p < 0.001). (F–I) <t>HIF1</t> <t>α</t> staining intensities: negative, weak, moderate, strong. (J) HIF1 α IHC scores ( p = 0.004). (K–N) p110 α staining intensities: negative, weak, moderate, strong. (O) p110 α IHC scores ( p = 0.039). All micrographs shown at ×200 magnification.
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    Image Search Results


    (A–D) UBE2S staining intensities: negative, weak, moderate, strong. (E) UBE2S IHC scores ( p < 0.001). (F–I) HIF1 α staining intensities: negative, weak, moderate, strong. (J) HIF1 α IHC scores ( p = 0.004). (K–N) p110 α staining intensities: negative, weak, moderate, strong. (O) p110 α IHC scores ( p = 0.039). All micrographs shown at ×200 magnification.

    Journal: PeerJ

    Article Title: UBE2S and HIF1α expression patterns and stratified analysis reveal prognostic value in esophageal squamous cell carcinoma

    doi: 10.7717/peerj.20694

    Figure Lengend Snippet: (A–D) UBE2S staining intensities: negative, weak, moderate, strong. (E) UBE2S IHC scores ( p < 0.001). (F–I) HIF1 α staining intensities: negative, weak, moderate, strong. (J) HIF1 α IHC scores ( p = 0.004). (K–N) p110 α staining intensities: negative, weak, moderate, strong. (O) p110 α IHC scores ( p = 0.039). All micrographs shown at ×200 magnification.

    Article Snippet: The primary antibodies used were: UBE2S (rabbit polyclonal, 14115-1-AP, 1:360; Proteintech), HIF1 α (rabbit monoclonal, bs-0737R, 1:400; BIOSS), and p110 α (rabbit polyclonal, C73F8, 1:250; ZSGB-Bio).

    Techniques: Staining

    (A, B) Pan-cancer mRNA expression analysis of UBE2S (A) and HIF1 α (B) across TCGA malignancies, indicating significant overexpression in ESCA. (C, D) Validation of UBE2S (C) and HIF1 α (D) mRNA overexpression in the TCGA-ESCA tumor cohort compared to a pooled normal tissue reference (integrating GTEx data; p < 0.001, Wilcoxon rank-sum test). (E, F) Independent validation in the GEO dataset ( GSE161533 ) confirms significant overexpression of UBE2S (E) and HIF1 α (F) in ESCC tissues compared to paired adjacent non-tumorous tissues ( p < 0.001). (G) Correlation analysis within the TCGA-ESCA cohort reveals a significant positive correlation between UBE2S and HIF1 α mRNA expression levels (Pearson’s correlation; R = 0.42, p = 0.0013).

    Journal: PeerJ

    Article Title: UBE2S and HIF1α expression patterns and stratified analysis reveal prognostic value in esophageal squamous cell carcinoma

    doi: 10.7717/peerj.20694

    Figure Lengend Snippet: (A, B) Pan-cancer mRNA expression analysis of UBE2S (A) and HIF1 α (B) across TCGA malignancies, indicating significant overexpression in ESCA. (C, D) Validation of UBE2S (C) and HIF1 α (D) mRNA overexpression in the TCGA-ESCA tumor cohort compared to a pooled normal tissue reference (integrating GTEx data; p < 0.001, Wilcoxon rank-sum test). (E, F) Independent validation in the GEO dataset ( GSE161533 ) confirms significant overexpression of UBE2S (E) and HIF1 α (F) in ESCC tissues compared to paired adjacent non-tumorous tissues ( p < 0.001). (G) Correlation analysis within the TCGA-ESCA cohort reveals a significant positive correlation between UBE2S and HIF1 α mRNA expression levels (Pearson’s correlation; R = 0.42, p = 0.0013).

    Article Snippet: The primary antibodies used were: UBE2S (rabbit polyclonal, 14115-1-AP, 1:360; Proteintech), HIF1 α (rabbit monoclonal, bs-0737R, 1:400; BIOSS), and p110 α (rabbit polyclonal, C73F8, 1:250; ZSGB-Bio).

    Techniques: Expressing, Over Expression, Biomarker Discovery

    (A, B) Kaplan–Meier survival curves showing that high expression of UBE2S is significantly associated with poorer overall survival (OS; p = 0.006) and progression-free survival (PFS; p = 0.034). (C, D) Similarly, high expression of HIF1 α is associated with reduced OS ( p < 0.001) and PFS ( p = 0.002). (E, F) Patients were stratified into four groups based on UBE2S and HIF1 α co-expression status: Group 1 (dual-negative), Group 2 (UBE2S-negative/HIF1 α -positive), Group 3 (UBE2S-positive/HIF1 α -negative), and Group 4 (dual-positive). Kaplan–Meier analysis revealed significant stratification of both OS ( p < 0.001) and PFS ( p = 0.005) among these groups, with patients exhibiting dual-positive expression (Group 4) demonstrating the poorest outcomes.

    Journal: PeerJ

    Article Title: UBE2S and HIF1α expression patterns and stratified analysis reveal prognostic value in esophageal squamous cell carcinoma

    doi: 10.7717/peerj.20694

    Figure Lengend Snippet: (A, B) Kaplan–Meier survival curves showing that high expression of UBE2S is significantly associated with poorer overall survival (OS; p = 0.006) and progression-free survival (PFS; p = 0.034). (C, D) Similarly, high expression of HIF1 α is associated with reduced OS ( p < 0.001) and PFS ( p = 0.002). (E, F) Patients were stratified into four groups based on UBE2S and HIF1 α co-expression status: Group 1 (dual-negative), Group 2 (UBE2S-negative/HIF1 α -positive), Group 3 (UBE2S-positive/HIF1 α -negative), and Group 4 (dual-positive). Kaplan–Meier analysis revealed significant stratification of both OS ( p < 0.001) and PFS ( p = 0.005) among these groups, with patients exhibiting dual-positive expression (Group 4) demonstrating the poorest outcomes.

    Article Snippet: The primary antibodies used were: UBE2S (rabbit polyclonal, 14115-1-AP, 1:360; Proteintech), HIF1 α (rabbit monoclonal, bs-0737R, 1:400; BIOSS), and p110 α (rabbit polyclonal, C73F8, 1:250; ZSGB-Bio).

    Techniques: Expressing